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Arch Virol. 1997;142(5):1035-43.

AZT blocks down-regulation of IL-2 and IFN-gamma gene expression in HIV acutely infected cells.

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National Centre for HIV Virology Research, Institute of Medical and Veterinary Science, Adelaide, Australia.


HIV infection causes dysregulation of cytokine gene expression in CD4+ T cells of the infected host. Azidothymidine (AZT) inhibits HIV replication by blocking reverse transcription. Using a one-stop cell-to-cell HIV infection model, we have investigated the expression of several key cytokines in HIV infected T cells in the absence or presence of AZT treatment. Acute HIV infection of T cells resulted in dramatic down regulation of the expression of IL-2 and INF-gamma mRNA. While beta-actin mRNA levels remained constant in both AZT-free and AZT treated cultures after HIV infection, it was found that AZT blocked the down regulation of IL-2 mRNA and INF-gamma mRNA in CD4+ T cells acutely infected with HIV.

[Indexed for MEDLINE]

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