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Brain Res Mol Brain Res. 1997 Jun;46(1-2):338-42.

Calcium- and calmodulin-dependent phosphorylation of AMPA type glutamate receptor subunits by endogenous protein kinases in the post-synaptic density.

Author information

1
Department of Neurophysiology, Institute for Brain Research, Faculty of Medicine, University of Tokyo, Japan.

Abstract

We have detected immunoreactivities of AMPA receptor subunits GluR1-4 in post-synaptic density (PSD) fraction and tested whether they can be phosphorylated by endogenous kinases. Incubation of PSD with Ca2+ and calmodulin increased phosphorylation of GluR1 and GluR2/3. The phosphorylation of GluR1 was largely blocked by a Ca2+/calmodulin-dependent protein kinase type II inhibitor. Thus Ca2+/calmodulin-dependent phosphorylation of glutamate receptor may be a mechanism underlying enhanced post-synaptic receptor responsiveness in LTP.

PMID:
9191113
DOI:
10.1016/s0169-328x(97)00073-9
[Indexed for MEDLINE]

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