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FEBS Lett. 1997 May 26;408(3):315-8.

Aluminum fluoride associates with the small guanine nucleotide binding proteins.

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1
Max-Planck-Institut für molekulare Physiologie, Dortmund, Germany.

Abstract

AlF4- has long been known to associate with and activate the GDP-bound alpha subunits of heterotrimeric G-proteins. Recently the small guanine nucleotide binding protein Ras has also been shown to associate with AlF4- in the presence of stoichiometric amounts of its GTPase activating protein (GAP). Here we present the isolation of a stable Ras x GDP- x AlF4- x GAP ternary complex by gel filtration. In addition, we generalise the association of AlF4- with the small GTP-binding proteins by demonstrating ternary complex formation for the Cdc42, Rap and Ran proteins in the presence of their respective GAP proteins.

PMID:
9188784
DOI:
10.1016/s0014-5793(97)00422-5
[Indexed for MEDLINE]
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