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Dermatology. 1997;194(3):268-72.

Combination of etoposide, idarubicin, cyclophosphamide, vincristine, prednisone and bleomycin (VICOP-B) in the treatment of advanced cutaneous T-cell lymphoma.

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1
Clinica Dermatologica I, dell'Università di Torino, Italy.

Abstract

BACKGROUND:

Response of cutaneous T-cell lymphoma (CTCL) to systemic chemotherapy is unsatisfactory: despite an initially high response rate (RR), duration is always short-lived.

OBJECTIVE:

To investigate the capability of a third-generation regimen including idarubicin in improving RR and response duration in CTCL patients.

METHODS:

Twenty-five patients with advanced CTCL (stages IIB and IV) were treated with a 12-week polychemotherapeutic regimen (VICOP-B), which foresees the use of idarubicin in association with etoposide, cyclophosphamide, vincristine, prednisone and bleomycin.

RESULTS:

The overall objective RR was 80% (36% complete response). The mycosis fungoides (MF) RR was 84%, with a median duration of 8.7 months. The pleomorphic-lymphoma RR was higher (100%), but the corresponding response duration was shorter (median: 3 months). No responses were documented in Sézary syndrome.

CONCLUSION:

VICOP-B regimen is effective and feasible as first-line chemotherapy in advanced MF, with or without extracutaneous involvement.

PMID:
9187846
DOI:
10.1159/000246116
[Indexed for MEDLINE]

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