Format

Send to

Choose Destination
See comment in PubMed Commons below
FEBS Lett. 1997 May 19;408(2):121-3.

Rolling in the clover: trefoil factor family (TFF)-domain peptides, cell migration and cancer.

Author information

1
Histopathology Unit, Imperial Cancer Research Fund, London, UK. nwright@rpms.ac.uk

Abstract

Trefoil factor family (TFF)-domain peptides 1-3 are mucin-associated molecules, largely found in epithelia of gastrointestinal tissues. Structurally similar, resistant to enzymatic degradation, they are up-regulated around areas of epithelial damage such as ulcers. Transgenic expression or exogenous peptide ameliorates or prevents gastric mucosal damage due to indomethacin and some are rapidly up-regulated after cryogenic burns. A role in promoting cell migration is strongly suggested. Knockout mice lacking TFF1 or TFF3 show significant pathology, with the former developing gastric tumours. A recent Conference Philippe Laudat agreed upon a new nomenclature for these peptides.

PMID:
9187350
[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Support Center