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J Affect Disord. 1997 May;43(3):195-205.

A chromosome 18 genetic linkage study in three large Belgian pedigrees with bipolar disorder.

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Center for Human Genetics, University of Leuven, Belgium.


The contribution of genetic factors to the susceptibility for affective disorders has been firmly established. Recent reports found evidence for a susceptibility locus for affective disorders in 2 regions on chromosome 18. We describe 3 large Belgian pedigrees with multiple patients with affective disorders. Both chromosome 18 regions were investigated in the 3 families, using parametric and nonparametric segregation methods. In the pericentromeric region, all evidence was against a disease gene in our families. Also the data obtained for the distal part of 18q, argue against a genetic susceptibility factor in our sample.

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