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Curr Opin Lipidol. 1997 Apr;8(2):111-7.

The role of 15-lipoxygenase in atherogenesis: pro- and antiatherogenic actions.

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Institute of Biochemistry, University Clinics Charité, Humboldt University, Berlin, Germany.


Oxidative modification converts LDL to an atherogenic form and 15-lipoxygenase has been implicated in this process. Several lines of experimental evidence support such a proatherogenic action of the enzyme. However, recent data obtained with transgenic rabbits overexpressing 15-lipoxygenase suggest also an antiatherogenic effect. In this paper the pathophysiological relevance of 15-lipoxygenase in atherogenesis is critically reviewed.

[Indexed for MEDLINE]

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