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Arthritis Rheum. 1997 Jun;40(6):1050-3.

Interleukin-17 up-regulation of nitric oxide production in human osteoarthritis cartilage.

Author information

1
Hospital for Joint Diseases, New York, New York 10003, USA.

Abstract

OBJECTIVE:

To examine the effect of human interleukin-17 (IL-17) on nitric oxide (NO) production in human osteoarthritis (OA) cartilage under ex vivo conditions.

METHODS:

OA cartilage from patients undergoing knee replacement surgery was used in explant assays to assess the effect of IL-17. NO production was measured by estimating the stable NO metabolite, nitrite, in conditioned medium.

RESULTS:

IL-17 augmented the spontaneous production of nitric oxide. This augmentation was sensitive to cycloheximide and pyrrolidine dithiocarbamate, but not to dexamethasone or soluble IL-1 receptor.

CONCLUSION:

IL-17 augments nitric oxide production in OA cartilage via nuclear factor kappaB activation, but independently of IL-1beta signaling.

PMID:
9182915
DOI:
10.1002/art.1780400609
[Indexed for MEDLINE]

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