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J Antimicrob Chemother. 1996 Mar;37(3):617-22.

Combination of 5-flucytosine and capsule-binding monoclonal antibody in the treatment of murine Cryptococcus neoformans infections and in vitro.

Author information

1
Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

Abstract

The efficacy of combination therapy with 5-flucytosine and an IgG1 monoclonal antibody to Cryptococcus neoformans capsular glucuronoxylomannan was studied in vitro with J774. 16 murine macrophage-like cells and in vivo in murine cryptococcal infection. The combination of 5-flucytosine and IgG1 was more effective in reducing the numbers of C. neoformans colony-forming units in vitro and in vivo than either agent alone.

PMID:
9182119
DOI:
10.1093/jac/37.3.617
[Indexed for MEDLINE]

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