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Infect Control Hosp Epidemiol. 1997 Jun;18(6):412-6.

Nosocomial respiratory syncytial virus infections: prevention and control in bone marrow transplant patients.

Author information

1
Section of Infectious Diseases, University of Texas M.D. Anderson Cancer Center, Houston 77030, USA.

Abstract

OBJECTIVE:

To assess the effectiveness of a multifaceted infection control strategy in limiting the nosocomial transmission of respiratory syncytial virus (RSV) infection to patients in a bone marrow transplant (BMT) unit.

DESIGN:

Before/after trial.

SETTING:

University-affiliated tertiary cancer center.

PATIENTS:

Adult BMT recipients hospitalized during two consecutive wintertime community outbreaks of RSV infection.

INTERVENTIONS:

An infection control strategy against nosocomial RSV infection was implemented in the BMT unit in February 1993. The strategy involved prompt identification, isolation, and cohorting of RSV-infected patients; prompt therapy with aerosolized ribavirin; use of masks and gloves by anyone entering an infected BMT patient's room; screening visitors for respiratory symptoms; restricting visitation by all children under 12 years of age and all family members and other visitors with RSV symptoms; and restricting symptomatic hospital staff from working in the BMT unit.

RESULTS:

After implementation of the multifaceted infection-control strategy, there were four cases of nosocomial RSV infection in 3,870 patient days (incidence density, 1.0 case/1,000 patient days) compared with 14 cases of nosocomial RSV infection in 3,152 patient days (incidence density, 4.4 cases/1,000 patient days) during the 1992-1993 RSV season (rate ratio, 4.4; 95% confidence interval [CI95]. 1.4-17.9: P < .01). This decrease in incidence occurred despite a comparable prevalence of community-acquired RSV cases between the two seasons (2.2% vs 3.2% in 1992-1993 and 1993-1994, respectively; prevalence ratio, 0.7; CI95, 0.2-2.1; P = 0.5).

CONCLUSION:

Institution of a multifaceted infection control strategy significantly reduced the frequency of nosocomial RSV infection in a high-risk group of adult BMT recipients.

PMID:
9181397
[Indexed for MEDLINE]

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