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Proc Natl Acad Sci U S A. 1997 Jun 10;94(12):6303-6.

Drosophila drop-dead mutations accelerate the time course of age-related markers.

Author information

1
Department of BioStructure and Function, School of Dental Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA.

Abstract

Mutations of the drop-dead gene in Drosophila melanogaster lead to striking early death of the adult animal. At different times, after emergence from the pupa, individual flies begin to stagger and, shortly thereafter, die. Anatomical examination reveals gross neuropathological lesions in the brain. The life span of flies mutant for the drop-dead gene is four to five times shorter than for normal adults. That raises the question whether loss of the normal gene product might set into motion a series of events typical of the normal aging process. We used molecular markers, the expression patterns of which, in normal flies, change with age in a manner that correlates with life span. In the drop-dead mutant, there is an acceleration in the temporal pattern of expression of these age-related markers.

PMID:
9177212
PMCID:
PMC21044
[Indexed for MEDLINE]
Free PMC Article

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