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Immunity. 1997 May;6(5):519-29.

Peptide antigen treatment of naive and virus-immune mice: antigen-specific tolerance versus immunopathology.

Author information

1
Institute of Experimental Immunology, Department of Pathology, University of Zurich, Switzerland.

Abstract

Peptide-specific down-regulation of T cell responses may represent a powerful tool to intervene in autoimmune diseases or graft rejections. It is therefore important to know whether peptide treatment tolerizes both naive and antigen-experienced memory T lymphocytes. Here we show that a major histocompatibility complex class I binding peptide, derived from the glycoprotein (GP33 peptide) of lymphocytic choriomeningitis virus (LCMV), specifically tolerized naive cytotoxic T lymphocytes (CTL) when administered three times intraperitoneally in incomplete Freund's adjuvants. However, in the presence of GP33-specific memory CTL in LCMV-primed mice, the same treatment had a general immunosuppressive effect on unrelated third-party antigen-specific T cell responses and caused severe immunopathological damage to the spleen.

PMID:
9175830
DOI:
10.1016/s1074-7613(00)80340-4
[Indexed for MEDLINE]
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