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Neuropharmacology. 1997 Mar;36(3):405-9.

Identification of pore-forming subunit of P-type calcium channels: an antisense study on rat cerebellar Purkinje cells in culture.

Author information

1
Lilly Research Centre, Eli Lilly Co. Ltd., Windlesham, Surrey, U.K.

Abstract

Treatment of cerebellar neurones in culture with an antisense oligonucleotide (ODN) against alpha1A, reduced the whole-cell P-type calcium channel current relative to mismatch ODN treated controls (p < 0.001). Therefore, AgaIVA (50 nM) reduced whole-cell calcium current in mismatch and antisense treated cells by 70 +/- 4 and 19 +/- 3%, respectively.

PMID:
9175621
DOI:
10.1016/s0028-3908(97)00046-4
[Indexed for MEDLINE]

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