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Trends Biochem Sci. 1997 May;22(5):172-6.

Two-component signal transducers and MAPK cascades.

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Division of Tumor Immunology, Dana-Farber Cancer Institute, Boston, MA, USA.


Two-component signal transducers, which are characterized by the histidine-to-aspartate phospho-transfer mechanism, were once thought to be restricted to prokaryotes. They have, however, now been identified in diverse eukaryotic species including plant, fungus, yeast and slime mold. In yeast, a two-component osmosensor has been found to regulate a mitogen-activated protein kinase (MAPK) cascade, a ubiquitous eukaryotic signaling module.

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