Format

Send to

Choose Destination
Trends Biochem Sci. 1997 May;22(5):162-6.

RNA editing: getting U into RNA.

Author information

1
Seattle Biomedical Research Institute, WA 98109, USA.

Abstract

RNA editing in kinetoplastid protozoa remodels the sequences of mitochondrial pre-mRNAs by the precise insertion and deletion of uridylate residues. These sequence changes are directed by small trans-acting RNAs, termed guide RNAs. The basic mechanistic pathway by which edited RNA is generated has recently been elucidated using in vitro systems capable of a full round of guide-RNA-directed editing.

PMID:
9175474
DOI:
10.1016/s0968-0004(97)01041-4
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center