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Trends Biochem Sci. 1997 May;22(5):157-62.

RNA editing and hypermutation by adenosine deamination.

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Department of Biochemistry, University of Utah, Salt Lake City 84112, USA.

Erratum in

  • Trends Biochem Sci 1997 Jul;22(7):278.


Double-stranded RNA adenosine deaminase (dsRAD) was discovered ten years ago. In the intervening decade, research on dsRAD has progressed not only predictably, such as with the purification of the enzyme and identification of cDNAs, but also in some quite surprising ways. This review covers both areas of progress, but will concentrate on the surprises, which include the discovery that dsRAD is a member of a larger family of deaminases and the identification of RNAs that appear to be targets for these deaminases in vivo.

[Indexed for MEDLINE]

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