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Scand J Gastroenterol. 1997 May;32(5):465-8.

High prevalence of the CagA-positive Helicobacter pylori strains in Japanese asymptomatic patients and gastric cancer patients.

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1
First Dept. of Internal Medicine, Hirosaki University School of Medicine, Japan.

Abstract

BACKGROUND:

Several studies have shown that infection of Helicobacter pylori strains possessing cagA is associated with atrophic gastritis and gastric cancers.

METHOD:

In 58 pairs of early gastric cancer patients and sex- and age-matched controls, isolated H. pylori strains were tested for possession of cagA. The presence of atrophic gastritis was also examined.

RESULTS:

Proportions of cagA-positive strains were 100% in cancer patients and 92.3% in controls. Atrophic gastritis was seen in 96.7% and 95.8% of cancer and control patients in whom cagA-positive strains (NS) were detected. However, it was seen in only 20% of H. pylori-negative control patients (P < 0.01).

CONCLUSIONS:

The present results do not suggest any specific association between cagA-positive strains and gastric cancer. However, frequent prevalence of cagA-positive strains might be associated with the high incidence of atrophic gastritis in Japanese populations.

PMID:
9175208
DOI:
10.3109/00365529709025082
[Indexed for MEDLINE]

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