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Oncology. 1977;34(3):129-32.

Investigations on prostatic adenocarcinomas in rats.

Abstract

Metastatic prostate adenocarcinomas, derived from aging germfree Wistar rats, have been propagated in rats and in tissue culture. A protocol has been developed and demonstrated for assay of treatments which retard or which accelerate the rate and extent of tumor growth and of metastasis in tumor-bearing rats. The pattern of spread has been retarded by cyclophosphamide, aspirin, indomethacin, and Corynebacterium parvum. The spread pattern has been accelerated by oral administrations of sodium barbiturate.

PMID:
917442
DOI:
10.1159/000225205
[Indexed for MEDLINE]

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