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Antimicrob Agents Chemother. 1997 Jun;41(6):1392-5.

Antifungal pharmacodynamic characteristics of fluconazole and amphotericin B tested against Candida albicans.

Author information

1
College of Pharmacy, University of Iowa, Iowa City 52242-1112, USA. michael-klepser@uiowa.edu

Abstract

Time-kill curves were determined for three isolates of Candida albicans tested against fluconazole and amphotericin B at multiples of the MIC. Fluconazole produced fungistatic activity, with concentration-related growth effects observed over a narrow range of concentrations. Amphotericin B exhibited fungicidal activity, with enhancement of activity over a broader range of concentrations.

PMID:
9174207
PMCID:
PMC163923
[Indexed for MEDLINE]
Free PMC Article

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