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Zh Vyssh Nerv Deiat Im I P Pavlova. 1997 Mar-Apr;47(2):362-73.

[Volume transmission as a means of interneuronal interaction in the striatum].

[Article in Russian]


This review of literature and own data is devoted to a special mode of intercellular communication in the GNS--volume transmission, that is based on diffusion of neuromediators from points of release through the brain extracellular space to distant non-synaptic receptor sites. Using the main neurotransmitters of the striatum (dopamine, glutamate and GABA) as an example, the author has analysed the evidence for the existence of volume transmission in this brain region, the tentative mechanisms underlying this mode for information processing, and receptors involved. Much attention has been paid to functional significance of volume transmission in the striatum for maintenance of behaviour, operated by this brain area.

[Indexed for MEDLINE]

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