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Minerva Ginecol. 1997 Mar;49(3):67-72.

[Conservative management of ectopic pregnancy].

[Article in Italian]

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Divisione di Ostetricia e Ginecologia, Istituto per l'Infanzia, IRCCS, Trieste.



The aim of this retrospective study was to analyze the safety and efficacy of the conservative approach in the management of ectopic pregnancy.


Thirty-five women with a tubal ectopic pregnancy, from 1990 to 1995, were subdivided into 2 treatment groups. Inclusion criteria were the following: tubal diameter < 3 cm, free fluid < 100 ml, no embryo heart activity, haemodynamic stability. Desire of future fertility and informed consent were requested. Eighteen women were treated with a single intramuscular injection of methotrexate, whereas in 17 cases expectant management was adopted.


In the first group 2 cases required surgical treatment (resolution rate = 89%). In the second group no surgery was needed and spontaneous resolution was achieved in all cases (100%). In both groups the average resolution time was about 17 days. Serum hCG-beta levels were monitored daily until resolution. The initial hCG-beta value and its following trend seem to be the most important prognostic factors.


More studies are indeed needed to establish the effect of conservative management on fertility after ectopic pregnancy.

[Indexed for MEDLINE]

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