Unidentified antioxidant defences of human plasma in immobilized patients: a possible relation to basic metabolic rate

Free Radic Res. 1997 Apr;26(4):335-41. doi: 10.3109/10715769709097813.

Abstract

Plasma total peroxyl radical scavenging capacity was studied in terminal patients who were chronically immobilized because of an acute (stroke) or chronic neurodegenerative disease (Alzheimer's disease). A luminometric assay was used to measure total antioxidant capacity (TRAP). The immobilized patients showed significant decrease in TRAP primarily because of a decrease in the concentration of unknown antioxidants. Our results suggest that human plasma may contain unknown antioxidants, the regulation of which could be related to the basic metabolic rate.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Alzheimer Disease / metabolism
  • Antioxidants / metabolism*
  • Ascorbic Acid / blood
  • Basal Metabolism*
  • Cerebrovascular Disorders / metabolism
  • Female
  • Humans
  • Immobilization*
  • Middle Aged
  • Sulfhydryl Compounds / blood
  • Uric Acid / blood
  • Vitamin E / blood

Substances

  • Antioxidants
  • Sulfhydryl Compounds
  • Vitamin E
  • Uric Acid
  • Ascorbic Acid