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Vet Hum Toxicol. 1997 Jun;39(3):152-4.

Hydrogen sulfide poisoning: an antidotal role for sodium nitrite?

Author information

1
Rocky Mountain Poison and Drug Center, Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver, USA.

Abstract

In 2 separate incidents, 6 patients were poisoned with hydrogen sulfide (H2S) in sewer gas. In the first incident, mixing acid- and sodium hydroxide-based drain cleaners in a confined space resulted in 4 poisonings and 2 deaths. Three would-be rescuers were seriously poisoned and 1 died. Two survivors had neurological sequelae. Sodium nitrite appeared to have some clinical efficacy in 1 case. The second incident involved 2 patients working on a pump in a sewage pond. A patient lying on a raft close to the pond surface was seriously poisoned; sodium nitrite was clinically efficacious and this patient survived without developing neurological sequelae. Sodium nitrite deserves further clinical study as a potential H2S antidote.

PMID:
9167244
[Indexed for MEDLINE]

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