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Am J Cardiol. 1997 May 1;79(9):1302-6.

Neurohormonal response to head-up tilt and its role in vasovagal syncope.

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Cardiology Department, Christchurch Hospital, New Zealand.


In a controlled study, 26 patients with a history of recurrent syncope were found to have increased arginine vasopressin, corticotrophin, and atrial natriuretic factor levels after 5 minutes of 60 degrees head-up tilt, long before they became hypotensive. The exaggerated neurohormonal response in these patients may indicate a greater sensitivity to central hypovolemia which may predispose to vasovagal syncope, mediated by the vasodilatory effects of atrial natriuretic factor or the sensitization of mechanoreceptors by arginine vasopressin.

[Indexed for MEDLINE]

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