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Genet Res. 1997 Feb;69(1):45-8.

Using the variance of pairwise differences to estimate the recombination rate.

Author information

1
Department of Biological Sciences, Rutgers University, New Jersey, USA. jwakeley@rci.rutgers.edu

Abstract

A new estimator is proposed for the parameter C = 4Nc, where N is the population size and c is the recombination rate in a finite population model without selection. The estimator is an improved version of Hudson's (1987) estimator, which takes advantage of some recent theoretical developments. The improvement is slight, but the smaller bias and standard error of the new estimator support its use. The variance of the average number of pairwise differences is also derived, and is important in the formulation of the new estimator.

PMID:
9164174
DOI:
10.1017/s0016672396002571
[Indexed for MEDLINE]

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