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Trends Microbiol. 1997 May;5(5):205-8.

Did the inheritance of a pathogenicity island modify the virulence of Helicobacter pylori?

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1
Dept of Molecular Biology, Immunobiological Research Institute of Siena (IRIS), Italy. covacci@iris02.biocine.it

Abstract

Strains of Helicobacter pylori from patients with peptic ulcer disease and gastric cancer contain a 40-kb fragment of DNA that is not present in isolates from carriers with asymptomatic infections. The discovery of the cag pathogenicity island suggests that virulence has evolved by quantum leaps through the inheritance of one or more DNA insertions.

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PMID:
9160510
DOI:
10.1016/S0966-842X(97)01035-4
[Indexed for MEDLINE]
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