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Eur J Gastroenterol Hepatol. 1997 Apr;9(4):367-70.

The Helicobacter pylori seroprevalence in blood donors related to Lewis (a,b) histo-blood group phenotype.

Author information

1
Institute of Experimental and Clinical Medicine, Tallinn, Estonia.

Abstract

OBJECTIVE:

To study a possible association of the Helicobacter pylori seroprevalence with ABO(H) and Lewis (a,b) blood group phenotypes in blood donors.

DESIGN:

A cross-sectional study of blood donors using ABO(H) and Lewis (a,b) blood group phenotype as predictors.

METHODS:

ABO(H) and Lewis (a,b) blood group phenotyping was performed with monoclonal antibody. The H. pylori immunoglobulin G (IgG) antibody relative activity was evaluated by enzyme-linked immunosorbent assay (ELISA) using acid glycine extract from H. pylori.

SUBJECTS:

One hundred and fifty-nine randomly selected blood transfusion donors.

RESULTS:

The individuals with Lewis (a+b-)/non-secretor phenotype showed a significantly higher proportion of the H. pylori-seronegative subjects and a lower IgG immune response to H. pylori antigens as compared with the individuals of Lewis (a-b+)/secretor phenotype.

CONCLUSION:

The Lewis (a,b) histo-blood group antigens are implicated in the mechanisms of naturally occurring resistance to H. pylori infection.

PMID:
9160199
[Indexed for MEDLINE]

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