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Br J Clin Pharmacol. 1997 May;43(5):467-70.

Lack of inhibitory effect of cimetidine on caffeine metabolism in children using the caffeine breath test.

Author information

1
Institute of Child Health, Alder Hey Children's Hospital, Liverpool, UK.

Abstract

AIMS:

To study the potential drug interaction between cimetidine and caffeine in a group of children who received cimetidine for gastritis.

METHODS:

The caffeine breath test was carried out prior to the administration of cimetidine and after 2-3 weeks therapy. The children (n = 1) received 300-800 mg cimetidine daily (11-36 mg kg(-1) day(-1)).

RESULTS:

There was no significant change in the 2 h cumulative labelled CO2 following the administration of cimetidine (mean values 5.61% before and 4.87% during cimetidine; Student's t-test P > 0.2).

CONCLUSIONS:

Cimetidine did not have an inhibitory effect on the metabolism of caffeine in this group of children studied.

PMID:
9159560
PMCID:
PMC2042773
DOI:
10.1046/j.1365-2125.1997.00589.x
[Indexed for MEDLINE]
Free PMC Article

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