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Curr Opin Cell Biol. 1997 Jun;9(3):320-8.

Protein functions in pre-mRNA splicing.

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  • 1Institut für Molekularbiologie und Tumorforschung, Philipps Universität Marburg, Emil Mannkopff Strasse 2, 35037, Marburg, Germany.


Proteins have been implicated in an expanding variety of functions during pre-mRNA splicing. Molecular cloning has identified genes encoding spliceosomal proteins that potentially act as novel RNA helicases, GTPases, or protein isomerases. Novel protein-protein and protein-RNA interactions that are required for functional spliceosome formation have also been described. Finally, growing evidence suggests that proteins may contribute directly to the spliceosome's active sites.

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