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Curr Opin Cell Biol. 1997 Jun;9(3):388-95.

Nuclear organization and gene expression: homologous pairing and long-range interactions.

Author information

1
Howard Hughes Medical Institute, Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98104, USA. steveh@howard.fhcrc.org

Abstract

Genetic studies have demonstrated that pairing interactions between homologous chromosomes and long-range associations between nonhomologous sites can influence gene expression. Recent work has revealed that such influences are widespread in eukaryotes and that chromosome architecture is likely to be of fundamental importance for nuclear structure and function.

PMID:
9159074
DOI:
10.1016/s0955-0674(97)80012-9
[Indexed for MEDLINE]

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