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Curr Opin Cell Biol. 1997 Jun;9(3):396-400.

The cytoskeleton in mRNA localization and cell differentiation.

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Research Institute of Molecular Pathology, Dr Bohr-Gasse 7, A-1030, Vienna, Austria.


Asymmetric distribution of cytoplasmic proteins and messenger RNAs has been implicated in several instances of cell differentiation. Microtubules have been suggested to direct mRNA localization in Drosophila and Xenopus oocytes but motor proteins that might transport mRNAs have not yet been identified. Recent data imply that in Drosophila, Caenorhabditis elegans and budding yeast, proteins of the actin cytoskeleton, including unconventional myosins, play active roles in the segregation of differentiation factors and mRNAs.

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