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Microb Drug Resist. 1996 Summer;2(2):225-9.

Peptidoglycan composition of vancomycin-resistant Enterococcus faecium.

Author information

1
Laboratory of Microbiology, Rockefeller University, New York, New York 10021, USA.

Abstract

Muropeptide composition of peptidoglycan isolated from isogenic vancomycin-resistant and sensitive Enterococcus faecium strains was analyzed by reverse-phase high-performance liquid chromatography combined with amino acid and fast atom bombardment mass spectrometric analyses. Peptidoglycan of the sensitive and resistant strains was the same and was composed of tri- and tetrapeptides stem peptide subunits with or without aspartate or asparagine substitutions on the epsilon-amino group of the lysine residue. Thus, the synthesis of lactate-terminating peptidoglycan precursors in vancomycin-resistant E. faecium did not affect the chemical composition of peptidoglycan.

PMID:
9158764
DOI:
10.1089/mdr.1996.2.225
[Indexed for MEDLINE]

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