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J Nat Prod. 1997 Mar;60(3):223-9.

Massetolides A-H, antimycobacterial cyclic depsipeptides produced by two pseudomonads isolated from marine habitats.

Author information

1
Department of Chemistry, University of British Columbia, Vancouver, Canada.

Abstract

Massetolides A-H (1-8), novel cyclic depsipeptides, and the known compound viscosin (9) have been isolated from cultures of two Pseudomonas sp. isolated from a marine alga and a marine tube worm, respectively. Massetolide A (1) and viscosin (9) exhibit in vitro antimicrobial activity against Mycobacterium tuberculosis and Mycobacterium avium-intracellulare. Precursor-directed biosynthesis has been used to generate unnatural massetolides 11-13 incorporating nonprotein amino acids.

PMID:
9157190
DOI:
10.1021/np9606456
[Indexed for MEDLINE]

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