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Int J Geriatr Psychiatry. 1997 Mar;12(3):319-22.

Selegiline in the treatment of behavioural disturbance in Alzheimer's disease.

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1
Department of Psychiatry, St James's Hospital, Dublin, Ireland.

Abstract

OBJECTIVE:

The purpose of this study was to examine the behavioural and cognitive effects of selegiline in a group of moderately behaviourally disturbed AD patients.

DESIGN:

This was a 14-week randomized double-blind placebo-controlled study of selegiline (10 mg) and placebo.

SETTING:

An outpatient clinic in an urban-based tertiary referral centre in the USA.

PATIENTS:

Twenty-five outpatients meeting NINCDS criteria for probable Alzheimer's disease with associated behavioural disturbance.

MEASURES:

The Brief Psychiatric Rating Scale (BPRS), the Dementia Mood Assessment Scale (DMAS) and the Alzheimer Disease Assessment Scale (Cognitive) (ADAS-COG).

RESULTS:

In the primary analysis, improvement on the BPRS and DMAS scores with selegeline treatment did not. reach statistical significance. A secondary analysis using a parallel design showed a significant benefit of drug treatment on BPRS scores with a trend towards improvement on the DMAS. Among the 10 subjects who could be tested, there was a significant improvement in cognitive function on the ADAS-COG with selegiline compared to placebo.

CONCLUSIONS:

Short-term selegiline treatment produced an improvement in behaviour and had a significant effect on cognition in a subset of testable patients.

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