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Eur J Clin Nutr. 1997 May;51(5):312-7.

A multi-center comparison of dual energy X-ray absorptiometers: in vivo and in vitro soft tissue measurement.

Author information

1
Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA.

Abstract

OBJECTIVE:

To assess intra- and inter-site soft tissue variability by dual energy X-ray absorptiometry (DXA).

DESIGN:

Cross-sectional trial.

SETTING:

Three medical research institutions.

SUBJECTS:

Five humans (in vivo) and four phantoms (in vitro), configured from two whole body phantoms with artificial skeletons and thickness overlays.

INTERVENTIONS:

Duplicate total-body DXA scans were performed on all subjects at each institution within a 15 d period.

RESULTS:

All intra-site coefficients of variation (CV) were < 0.5% for total tissue mass, but in vitro and in vivo Cvs were 7.2% and 2.3% for fat mass (FM) and 2.5% and 0.9% for lean mass (LM), respectively. Several total-body and regional FM and LM measurements were significantly different between sites (P < 0.05), with percent differences between sites ranging from 2.6-13.3% for FM and from 1.6-13.6% for LM. Site 2 was consistently lower for FM and Site 3 was consistently lower for LM.

CONCLUSIONS:

These results stress the need for both rigorous and standardized cross-calibration procedures for soft tissue measurement by DXA.

PMID:
9152682
[Indexed for MEDLINE]
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