Format

Send to

Choose Destination
See comment in PubMed Commons below
Arch Neurol. 1997 May;54(5):531-3.

Treatment of depression improves adherence to interferon beta-1b therapy for multiple sclerosis.

Author information

  • 1University of California, San Francisco, USA.

Abstract

OBJECTIVES:

To examine the relationship between patient-reported depression and adherence to therapy with interferon beta-1b (IFN beta-1b) and to test the hypothesis that treatment of depression is associated with improved adherence.

DESIGN:

Patients with multiple sclerosis were followed up 6 months after initiating therapy with IFN beta-1b.

SETTING:

A university outpatient multiple sclerosis center, an academic group practice, and a health maintenance organization.

PATIENTS:

Eighty-five patients with clinically evident multiple sclerosis taking IFN beta-1b.

MAIN OUTCOME MEASURE:

Follow-up questionnaire.

RESULTS:

Thirty-five (41%) of the 85 patients reported new or increased depression within 6 months of initiating therapy with IFN beta-1b. Patients experiencing symptoms of depression were more likely to discontinue therapy. Among the patients reporting new or increased depression, 86% who received psychotherapy or antidepressant medication and 38% of the patients who received no therapy for depression continued the IFN beta-1b therapy (P = .003). Although psychotherapy was used as a treatment option more frequently in university and academic group practice-based multiple sclerosis clinics than in the health maintenance organization (P = .02), the treatment adherence patterns were similar across sites.

CONCLUSIONS:

These findings support previous findings that patients report increased depression after initiating therapy with IFN beta-1b. Although the source of this depression is unclear, these findings suggest that treating patient-reported depression increases adherence to treatment.

PMID:
9152109
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Silverchair Information Systems
    Loading ...
    Support Center