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J Bacteriol. 1997 May;179(10):3362-4.

Exchange of glutamate and gamma-aminobutyrate in a Lactobacillus strain.

Author information

1
Soy Sauce Research Laboratory, R & D Division of Kikkoman Corporation, Noda City, Chiba, Japan. LDY05507@niftyserve.or.jp

Abstract

Lactobacillus sp. strain E1 catalyzed the decarboxylation of glutamate (Glu), resulting in a nearly stoichiometric release of the products gamma-aminobutyrate (GABA) and CO2. This decarboxylation was associated with the net synthesis of ATP. ATP synthesis was inhibited almost completely by nigericin and about 70% by N,N'-dicyclohexylcarbodiimide (DCCD), without inhibition of the decarboxylation. These findings are consistent with the possibility that a proton motive force arises from the cytoplasmic proton consumption that accompanies glutamate decarboxylation and the electrogenic Glu/GABA antiporter and the possibility that this proton motive force is coupled with ATP synthesis by DCCD-sensitive ATPase.

PMID:
9150237
PMCID:
PMC179120
[Indexed for MEDLINE]
Free PMC Article
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