Histone acetylation: chromatin in action

Trends Biochem Sci. 1997 Apr;22(4):128-32. doi: 10.1016/s0968-0004(97)01016-5.

Abstract

Histone acetylation acts as a landmark and determinant for chromatin function. Active roles in the transcription and assembly of chromatin have been discovered for histone acetyltransferases and deacetylases. This review highlights these roles and discusses their significance for the maintenance of cell differentiation.

Publication types

  • Review

MeSH terms

  • Acetylation
  • Acetyltransferases / genetics
  • Acetyltransferases / metabolism
  • Cell Cycle / genetics*
  • Cell Differentiation / genetics
  • Chromatin / genetics
  • Chromatin / metabolism*
  • Histone Acetyltransferases
  • Histones / genetics
  • Histones / metabolism*
  • Mitosis
  • Saccharomyces cerevisiae Proteins*
  • Transcription, Genetic*

Substances

  • Chromatin
  • Histones
  • Saccharomyces cerevisiae Proteins
  • Acetyltransferases
  • Histone Acetyltransferases