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Trends Biochem Sci. 1997 Apr;22(4):124-8.

Silencers and locus control regions: opposite sides of the same coin.

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Laboratory of Molecular Embryology, NICHD, Bethesda, MD 20892, USA.


Whether or not genes are in an active or a repressed state in a cell depends on the relative effect of gene silencers and locus control regions (LCRs). Here, we suggest that these elements act as binary switches; the state that prevails (activated or repressed) probably depends on a competition between protein complex formation and the stability of the complexes formed at either of the two elements.

[Indexed for MEDLINE]

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