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J Oral Pathol Med. 1996 Mar;25(3):112-8.

Heterogeneity of ICAM-1 expression, and cytokine regulation of ICAM-1 expression, in skin and oral keratinocytes.

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The Clinical Academic Group of Oral Medicine and Dental Diagnostic Science, University of Manchester School of Dental Science, Manchester, England.


Differences in expression of intercellular adhesion molecule-1 (ICAM-1) and ICAM-1 mRNA levels were studied in cultured skin and oral keratinocytes before and after stimulation with different pro-inflammatory cytokines. Basal expression of ICAM-1 was undetectable on skin keratinocytes but oral keratinocytes expressed ICAM-1 at high levels. Interferon-gamma (IFN-gamma) and tumor necrosis factor-alpha (TNF-alpha) increased ICAM-1 expression on both cell types, although TNF-alpha had a greater effect on oral than skin keratinocytes (P<0.05) and IFN-gamma was more effective than TNF-alpha on both cell types (P<0.01). In combination, TNF-alpha and IFN-gamma synergistically increased ICAM-1 expression on skin keratinocytes only, although ICAM-1 mRNA was synergistically increased in both cell types. IL-1alpha and IL-1beta induced a small increase in ICAM-1 expression on oral keratinocytes but had no effect on skin keratinocytes.

[Indexed for MEDLINE]

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