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AIDS. 1997 Mar;11(3):289-95.

Cerebral proton magnetic resonance spectroscopy in asymptomatic HIV infection.

Author information

1
Department of Medical Physics and Bioengineering, Middlesex Hospital, University College London Hospitals, NHS Trust, UK.

Abstract

OBJECTIVE:

To determine whether proton magnetic resonance spectroscopy (MRS) demonstrates central nervous system abnormalities in asymptomatic HIV-1-infected individuals.

DESIGN:

Both prospective and retrospective cross-sectional analyses of MRS in asymptomatic HIV-infected individuals.

SETTING:

Two specialists HIV/AIDS outpatient facilities in London.

PARTICIPANTS:

Eighty-four HIV-1 seropositive asymptomatic men; 29 HIV-1 antibody-negative homosexual men at high-risk for HIV infection and 48 HIV-1 antibody-negative men at low-risk for HIV infection as controls.

MAIN OUTCOME MEASURES:

Single voxel, gradient-localized proton MRS performed at 1.5 T with 135 msec echo-time and 1,600 msec repeat-time in an 8 ml volume of interest positioned in the parieto-occipital white matter. Spectroscopic results were expressed as ratios between the areas under the N-acetyl (NA), creatine (Cr) and choline (Cho) resonance peaks.

RESULTS:

There were no differences between those controls at high and those at low-risk for HIV infection. Comparing the combined control groups with the asymptomatic seropositive patients there were statistically significant differences in NA/Cho, NA/Cr (both P < 0.05) and NA/(NA + Cho + Cr) (P < 0.01).

CONCLUSION:

Abnormalities in cerebral biochemistry may be demonstrated by proton MRS during asymptomatic HIV-1 infection.

[Indexed for MEDLINE]

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