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Aliment Pharmacol Ther. 1997 Apr;11(2):415-7.

Acyclovir-induced colitis.

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Department of Medicine, Countess of Chester Hospital, Liverpool, UK.


Three patients developed acute colitis, either de novo, or as an exacerbation of pre-existing colitis, following the use of oral acyclovir, prescribed for Herpes zoster or Herpes simplex infection. Rechallenge with oral acyclovir was performed in one patient, and resulted in a recurrence of colitic symptoms. It is speculated that acyclovir can have a direct irritant effect on large bowel mucosa.

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