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J Urol. 1997 Jun;157(6):2179-82.

Biological variation of total, free and percent free serum prostate specific antigen levels in screening volunteers.

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1
Division of Urologic Surgery, Washington University School of Medicine, St. Louis, Missouri, USA.

Abstract

PURPOSE:

We determined the biological variation of the total, free and percent free serum prostate specific antigen (PSA) in men 50 years old or older.

MATERIALS AND METHODS:

Between July 1995 and February 1996 we studied 84 healthy men from our PSA screening study to determine biological variation by calculating the coefficients of variation of 3 PSA measurements on blood samples drawn from each subject 2 weeks apart.

RESULTS:

The mean coefficients of variation for total, free and percent free serum PSA were 15, 17 and 14%, respectively. Age, total PSA and ejaculation were not confounding factors in this analysis (that is multivariate R2 less than 5% for all indexes).

CONCLUSIONS:

There is a mean variation of approximately 15% in measurements of total, free and percent free PSA that does not appear to be significantly affected by age and total PSA level.

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PMID:
9146610
[Indexed for MEDLINE]

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