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Nat Struct Biol. 1997 May;4(5):342-9.

Interaction of Hsp70 chaperones with substrates.

Author information

1
Zentrum für Molekulare Biologie, Universität Heidelberg, Germany.

Abstract

Determination of the structure of the substrate binding domain of the Escherichia coli Hsp70 chaperone, DnaK, and the biochemical characterisation of the motif it recognizes within substrates provide insights into the principles governing Hsp70 interaction with polypeptide chains. DnaK recognizes extended peptide strands composed of up to five consecutive hydrophobic residues within and positively charged residues outside the substrate binding cavity.

PMID:
9145101
[Indexed for MEDLINE]

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