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Proc Natl Acad Sci U S A. 1997 May 13;94(10):5084-9.

Mapmodulin: a possible modulator of the interaction of microtubule-associated proteins with microtubules.

Author information

1
Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305-5307, USA.

Abstract

We have purified and characterized a 31-kDa protein named mapmodulin that binds to the microtubule-associated proteins (MAPs) MAP2, MAP4, and tau. Mapmodulin binds free MAPs in strong preference to microtubule-associated MAPs, and appears to do so via the MAP's tubulin-binding domain. Mapmodulin inhibits the initial rate of MAP2 binding to microtubules, a property that may allow mapmodulin to displace MAPs from the path of organelles translocating along microtubules. In support of this possibility, mapmodulin stimulates the microtubule- and dynein-dependent localization of Golgi complexes in semi-intact CHO cells. To our knowledge, mapmodulin represents the first example of a protein that can bind and potentially regulate multiple MAP proteins.

PMID:
9144194
PMCID:
PMC24635
[Indexed for MEDLINE]
Free PMC Article

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