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Annu Rev Immunol. 1997;15:453-79.

Initiation and processing of signals from the B cell antigen receptor.

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Department of Molecular Immunology, Biology III, University Freiburg, Germany.


Current models of signal transduction from the antigen receptors on B and T cells still resemble equations with several unknown elements. Data from recent knockout experiments in cell lines and mice contradict the assumption that Src-family kinase and tyrosine kinases of the Syk/Zap-70 family are the transducer elements that set signaling from these receptors in motion. Using a functional definition of signaling elements, we discuss the current knowledge of signaling events from the BCR and suggest the existence of an as-yet-unknown BCR transducer complex.

[Indexed for MEDLINE]

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