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Curr Opin Neurobiol. 1997 Apr;7(2):285-9.

Schizophrenia: a disorder of neurodevelopment?

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  • 1Department of Psychiatry, Warneford Hospital, University of Oxford, OX3 7JX, UK.


For the first time, there is a pathogenic hypothesis of schizophrenia based upon reasonable empirical data. The hypothesis is that schizophrenia is a disorder arising from aberrant brain development. The neurodevelopmental view of schizophrenia is supported by neuropathological, epidemiological and clinical findings. Here, the evidence in favour of the model is summarized, together with a consideration of its weaknesses.

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