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Trends Microbiol. 1997 Apr;5(4):148-56.

Type III secretion systems: machines to deliver bacterial proteins into eukaryotic cells?

Author information

1
Dept of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA. clee@warren.med.harvard.edu

Abstract

Type III secretion systems in certain bacterial pathogens are induced upon contact with host cells and directly deliver virulence proteins into the host cell cytosol. The increasing number of Gram-negative bacterial pathogens discovered to encode type III secretion systems raises interesting questions. Are type III systems generic machines that deliver virulence proteins into host cells? Is contact with host cells a common regulatory cue for type III systems?

PMID:
9141189
DOI:
10.1016/S0966-842X(97)01029-9
[Indexed for MEDLINE]

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