A human homolog of the vaccinia virus HindIII K4L gene is a member of the phospholipase D superfamily

J X Cao; B F Koop; C Upton

doi:10.1016/s0168-1702(96)01422-0

A human homolog of the vaccinia virus HindIII K4L gene is a member of the phospholipase D superfamily

Virus Res. 1997 Apr;48(1):11-8. doi: 10.1016/s0168-1702(96)01422-0.

Authors

J X Cao¹, B F Koop, C Upton

Affiliation

¹ Department of Biochemistry and Microbiology, University of Victoria, British Columbia, Canada.

PMID: 9140189
DOI: 10.1016/s0168-1702(96)01422-0

Abstract

We have identified a human gene encoding a protein with 48% amino acid identity to the vaccinia virus (VV) K4L gene product. Both contain motifs characteristic of the phospholipase D (PLD) protein superfamily. These proteins are also related to vaccinia virus p37, encoded by the F13L gene, which is required for envelopment and spread of the virus. The similarity to phospholipase D provides insight into the mechanisms and evolution of these processes.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Sequence
Animals
Base Sequence
DNA, Complementary
Deoxyribonuclease HindIII
Humans
Membrane Proteins / genetics
Molecular Sequence Data
Open Reading Frames
Phospholipase D / genetics*
Sequence Homology, Amino Acid
Vaccinia virus / genetics*
Viral Envelope Proteins / genetics*

Substances

DNA, Complementary
Membrane Proteins
Viral Envelope Proteins
p37 protein, Vaccinia virus
Deoxyribonuclease HindIII
Phospholipase D

Associated data

GENBANK/H15746
GENBANK/M19469
GENBANK/U28943
GENBANK/U43549
GENBANK/U60644