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Nature. 1997 May 1;387(6628):49-55.

Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression.

Author information

1
Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, New York 10461, USA.

Abstract

Normal mammalian growth and development are highly dependent on the regulation of the expression and activity of the Myc family of transcription factors. Mxi1-mediated inhibition of Myc activities requires interaction with mammalian Sin3A or Sin3B proteins, which have been purported to act as scaffolds for additional co-repressor factors. The identification of two such Sin3-associated factors, the nuclear receptor co-repressor (N-CoR) and histone deacetylase (HD1), provides a basis for Mxi1/Sin3-induced transcriptional repression and tumour suppression.

PMID:
9139821
DOI:
10.1038/387049a0
[Indexed for MEDLINE]

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